Research Faculty

Johanna Moore

Johanna Moore

Dr. Moore is the Research Director and the Director of Laboratory Research for the Department of Emergency Medicine. She completed a research fellowship in 2012 at HCMC, and is the author of over 20 peer-reviewed publications. She is an Assistant Professor of Emergency Medicine at the University of Minnesota.  Her research interests focus on enhancing perfusion during cardiac arrest through mechanisms such as Head Up CPR, and also Exception From Informed Consent (EFIC). She works closely with Dr. Lurie in the cardiac resuscitation laboratory, and with Dr. Ho and the EMS system, primarily regarding cardiac arrest management in the prehospital setting.

Brian Driver

Brian Driver

Dr. Driver is the Director of Clinical Research for Department of Emergency Medicine.  He is the author of many peer-reviewed manuscripts and is an Assistant Professor at the University of Minnesota. Research interests include emergency airway management, efficient ED evaluations, medical dogma, and general EM practice.

James Miner

James Miner

Dr. Miner is a Professor of Emergency Medicine at the University of Minnesota, and has conducted research in the areas of pain management and procedural sedation in the Emergency Department.  He is an author of over 100 peer reviewed manuscripts, edited a textbook on pain management and sedation (Emergency Pain and Sedation, Cambridge University Press, 2008) and has authored chapters about pain management and sedation in several other textbooks. He also conducts research in the effects of poverty on patients seen in the Emergency Department.

Michelle Biros

Michelle Biros

Dr. Biros is a nationally and internationally renowned researcher who has been inducted into the Institute of Medicine (IOM) predominantly for her work developing Exception From Informed Consent (EFIC) guidelines.  EFIC is what currently allows us to conduct research on emergency critical care and life saving interventions when critically ill or injured patients present without the ability to consent and without accompanying family members.  Dr. Biros also was Editor-In-Chief for Academic Emergency Medicine during the journal’s formative years, taking this journal from it’s inception and developing it into one of the most well read and well respected EM journals in the country, and the world.

The Strong History of Emergency Medicine Research at Hennepin

For more than 40 years the Emergency Department at HCMC has published innovative and high-quality research that has shaped the practice of emergency medicine. Here is a sample of landmark research conducted at HCMC:

Clinton, J. E., S. Sterner, Z. Stelmachers, and E. Ruiz. 1987. “Haloperidol for Sedation of Disruptive Emergency Patients.” Annals of Emergency Medicine 16 (3). Elsevier: 319–22.

McGill, J., J. E. Clinton, and E. Ruiz. 1982. “Cricothyrotomy in the Emergency Department.” Annals of Emergency Medicine 11 (7). Elsevier: 361–64.

Erlandson, M. J., J. E. Clinton, E. Ruiz, and J. Cohen. 1989. “Cricothyrotomy in the Emergency Department Revisited.” The Journal of Emergency Medicine 7 (2). Elsevier: 115–18.

Coon, G. A., J. E. Clinton, and E. Ruiz. 1981. “Use of Atropine for Brady-Asystolic Prehospital Cardiac Arrest.” Annals of Emergency Medicine 10 (9). Elsevier: 462–67.

Roberts, D. J., J. E. Clinton, and E. Ruiz. 1986. “Neuromuscular Blockade for Critical Patients in the Emergency Department.” Annals of Emergency Medicine 15 (2). Elsevier: 152–56.

Mirick, M. J., J. E. Clinton, and E. Ruiz. 1979. “External Rotation Method of Shoulder Dislocation Reduction.” JACEP 8 (12). Elsevier: 528–31.

Gravett, A., S. Sterner, J. E. Clinton, and E. Ruiz. 1987. “A Trial of Povidone-Iodine in the Prevention of Infection in Sutured Lacerations.” Annals of Emergency Medicine 16 (2). Elsevier: 167–71.

Mlinek, E. J., Jr, J. E. Clinton, D. Plummer, and E. Ruiz. 1990. “Fiberoptic Intubation in the Emergency Department.” Annals of Emergency Medicine 19 (4). Elsevier: 359–62.

Sterner, S., D. W. Plummer, J. Clinton, and E. Ruiz. 1986. “A Comparison of the Supraclavicular Approach and the Infraclavicular Approach for Subclavian Vein Catheterization.” Annals of Emergency Medicine 15 (4). Elsevier: 421–24.

Hammargren, Y., J. E. Clinton, and E. Ruiz. 1985. “A Standard Comparison of Esophageal Obturator Airway and Endotracheal Tube Ventilation in Cardiac Arrest.” Annals of Emergency Medicine 14 (10). Elsevier: 953–58.

Clinton, J. E., P. M. Zoll, R. Zoll, and E. Ruiz. 1985. “Emergency Noninvasive External Cardiac Pacing.” The Journal of Emergency Medicine 2 (3). Elsevier: 155–62.

Plummer, D., C. Dick, E. Ruiz, J. Clinton, and D. Brunette. 1994. “Emergency Department Two-Dimensional Echocardiography in the Diagnosis of Nontraumatic Cardiac Rupture.”Annals of Emergency Medicine 23 (6). Elsevier: 1333–42.

Mahoney, B. D., G. L. Rockswold, E. Ruiz, and J. E. Clinton. 1981. “Emergency Twist Drill Trephination.” Neurosurgery 8 (5). journals.lww.com: 551–54.

Clinton, Joseph E., and Ernest Ruiz. 1988. “Emergency Airway Management: Methods to Meet the Challenge.” Advanced Emergency Nursing Journal 10 (1). journals.lww.com: 31.

Clinton, J. E., J. McGill, G. Irwin, G. Peterson, G. P. Lilja, and E. Ruiz. 1984. “Cardiac Arrest under Age 40: Etiology and Prognosis.” Annals of Emergency Medicine 13 (11). Elsevier: 1011–15.

Adkinson, C., B. Roller, J. Clinton, E. Ruiz, and M. Bretzke. 1989. “A Comparison of Open Peritoneal Lavage with Modified Closed Peritoneal Lavage in Blunt Abdominal Trauma.” The American Journal of Emergency Medicine 7 (4). Elsevier: 352–56.

LeTourneau, Barbara, Carl N. Blegen, Joseph E. Clinton, and Ernest Ruiz. 1980. “Critical Care in an Emergency Department.” Annals of Emergency Medicine 9 (3). Elsevier: 126–30.

Thompson, J. D., S. Fish, and E. Ruiz. 1982. “Succinylcholine for Endotracheal Intubation.” Annals of Emergency Medicine 11 (10). Elsevier: 526–29.

Yaron, M., E. Ruiz, and M. F. Baretich. 1994. “Equipment Organization in the Emergency Department Adult Resuscitation Area.” The Journal of Emergency Medicine 12 (6). Elsevier: 845–48.

Sharkey, S. W., D. D. Bruneete, E. Ruiz, W. T. Hession, D. G. Wysham, I. F. Goldenberg, and M. Hodges. 1989. “An Analysis of Time Delays Preceding Thrombolysis for Acute Myocardial Infarction.” JAMA: The Journal of the American Medical Association 262 (22). jama.jamanetwork.com: 3171–74.

Wickstrom, P., E. Ruiz, G. P. Lija, J. P. Hinterkopf, and J. J. Haglin. 1976. “Accidental Hypothermia: Core Rewarming with Partial Bypass.” American Journal of Surgery 131 (5). Elsevier: 622–25.

Plummer, D., D. Brunette, R. Asinger, and E. Ruiz. 1992. “Emergency Department Echocardiography Improves Outcome in Penetrating Cardiac Injury.” Annals of Emergency Medicine 21 (6). Elsevier: 709–12.

Rockswold, G., B. Sharma, E. Ruiz, R. Asinger, M. Hodges, and M. Brieter. 1979. “Follow-up of 514 Consecutive Patients with Cardiopulmonary Arrest Outside the Hospital.” JACEP 8 (6). Elsevier: 216–20.

Glauser, J., G. P. Lilja, B. Greenfeld, and E. Ruiz. 1979. “Intravenous Glucagon in the Management of Esophageal Food Obstruction.” JACEP 8 (6). Elsevier: 228–31.

Gustilo, R. B., L. Simpson, R. Nixon, A. Ruiz, and W. Indeck. 1969. “Analysis of 511 Open Fractures.” Clinical Orthopaedics and Related Research 66 (September). journals.lww.com: 148–54.

Lilja, G. P., R. S. Long, and E. Ruiz. 1981. “Augmentation of Systolic Blood Pressure during External Cardiac Compression by Use of the MAST Suit.” Annals of Emergency Medicine 10 (4). Elsevier: 182–84.

Manoguerra, A. S., and E. Ruiz. 1976. “Physostigmine Treatment of Anticholinergic Poisoning.” JACEP 5 (2). Elsevier: 125–27.

Brunette, Douglas D., Michelle Biros, Edward J. Mlinek, Carol Erlandson, and Ernest Ruiz. 1992. “Internal Cardiac Massage and Mediastinal Irrigation in Hypothermic Cardiac Arrest.” The American Journal of Emergency Medicine 10 (1). Elsevier: 32–34.

Blake, D. P., V. L. Gisbert, A. L. Ney, H. K. Helseth, D. W. Plummer, E. Ruiz, and M. P. Bubrick. 1992. “Survival after Emergency Department versus Operating Room Thoracotomy for Penetrating Cardiac Injuries.” The American Surgeon 58 (6). europepmc.org: 329–32.

Mahoney, B. D., D. Gerdes, B. Roller, and E. Ruiz. 1984. “Aortic Compressor for Aortic Occlusion in Hemorrhagic Shock.” Annals of Emergency Medicine 13 (1). Elsevier: 11–16.

The Research Tradition Continues

We continue this tradition today with research that continues to improve the practice of emergency medicine with our key research faculty Dr. James Miner, Dr. Johanna Moore, Dr. Brian Driver, Dr. Matt Prekker, and Dr. Jon Cole.  Our core areas of research include emergency pain and sedation management, cardiac arrest, emergency airway management, agitation, toxicology, and many others.  A sampling of research from the past 15 years is copied below:

Driver, Brian E., Gautam R. Shroff, and Stephen W. Smith. 2017. “Posterior Reperfusion T-Waves: Wellens’ Syndrome of the Posterior Wall.” Emergency Medicine Journal: EMJ 34 (2). emj.bmj.com: 119–23.

Driver, Brian E., and John W. McGill. 2017. “Emergency Department Airway Management of Severe Angioedema: A Video Review of 45 Intubations.” Annals of Emergency Medicine, January. Elsevier. doi:10.1016/j.annemergmed.2016.11.027.

Driver, Brian E., Matthew E. Prekker, Rebecca L. Kornas, Ellen K. Cales, and Robert F. Reardon. 2017. “Flush Rate Oxygen for Emergency Airway Preoxygenation.” Annals of Emergency Medicine 69 (1). Elsevier: 1–6.

Driver, Brian E., Travis D. Olives, Johanna E. Bischof, Marcus R. Salmen, and James R. Miner. 2016. “Discharge Glucose Is Not Associated With Short-Term Adverse Outcomes in Emergency Department Patients With Moderate to Severe Hyperglycemia.” Annals of Emergency Medicine 68 (6). Elsevier: 697–705.e3.

Driver, Brian E., David Plummer, William Heegaard, and Robert F. Reardon. 2016. “Tracheal Malplacement of the King LT Airway May Be an Important Cause of Prehospital Device Failure.” The Journal of Emergency Medicine 51 (6). Elsevier: e133–35.

Cole, Jon B., Johanna C. Moore, Paul C. Nystrom, Benjamin S. Orozco, Samuel J. Stellpflug, Rebecca L. Kornas, Brandon J. Fryza, et al. 2016. “A Prospective Study of Ketamine versus Haloperidol for Severe Prehospital Agitation.” Clinical Toxicology 54 (7). Taylor & Francis: 556–62.

Ryu, Hyun Ho, Johanna C. Moore, Demetris Yannopoulos, Michael Lick, Scott McKnite, Sang Do Shin, Tae Yun Kim, et al. 2016. “The Effect of Head Up Cardiopulmonary Resuscitation on Cerebral and Systemic Hemodynamics.” Resuscitation 102 (May). Elsevier: 29–34.

Dodd, Kenneth W., Rebecca L. Kornas, Matthew E. Prekker, Lauren R. Klein, Robert F. Reardon, and Brian E. Driver. 2016. “Endotracheal Intubation with the King Laryngeal TubeTM In Situ Using Video Laryngoscopy and a Bougie: A Retrospective Case Series and Cadaveric Crossover Study.” The Journal of Emergency Medicine. Elsevier.http://www.sciencedirect.com/science/article/pii/S0736467916309064.

Driver, Brian E., Matthew E. Prekker, Johanna C. Moore, Alexandra L. Schick, Robert F. Reardon, and James R. Miner. 2016. “Direct Versus Video Laryngoscopy Using the C-MAC for Tracheal Intubation in the Emergency Department, a Randomized Controlled Trial.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 23 (4). Wiley Online Library: 433–39.

Miner, James R., Johanna C. Moore, Erin J. Austad, David Plummer, Laura Hubbard, and Richard O. Gray. 2015/5. “Randomized, Double-Blinded, Clinical Trial of Propofol, 1:1 Propofol/Ketamine, and 4:1 Propofol/Ketamine for Deep Procedural Sedation in the Emergency Department.” Annals of Emergency Medicine 65 (5). Elsevier: 479–88.e2.

Miner, James R., Johanna C. Moore, David Plummer, Richard O. Gray, Sagar Patel, and Jeffrey D. Ho. 2013. “Randomized Clinical Trial of the Effect of Supplemental Opioids in Procedural Sedation with Propofol on Serum Catecholamines.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 20 (4). Wiley Online Library: 330–37.

Miner, James R., Richard Gray, Parissa Delavari, Sagar Patel, Roma Patel, and David Plummer. 2011. “Alfentanil for Procedural Sedation in the Emergency Department.”Annals of Emergency Medicine 57 (2). Elsevier: 117–21.

Miner, James R., Richard O. Gray, Jennifer Bahr, Roma Patel, and John W. McGill. 2010. “Randomized Clinical Trial of Propofol versus Ketamine for Procedural Sedation in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 17 (6). Wiley Online Library: 604–11.

Deitch, Kenneth, Jim Miner, Carl R. Chudnofsky, Paul Dominici, and Daniel Latta. 2010. “Does End Tidal CO 2 Monitoring during Emergency Department Procedural Sedation and Analgesia with Propofol Decrease the Incidence of Hypoxic Events? A Randomized, Controlled Trial.” Annals of Emergency Medicine 55 (3). Elsevier: 258–64.

Hill, Chandler, Robert Reardon, Scott Joing, Dan Falvey, and James Miner. 2010. “Cricothyrotomy Technique Using Gum Elastic Bougie Is Faster than Standard Technique: A Study of Emergency Medicine Residents and Medical Students in an Animal Lab.”Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 17 (6). Wiley Online Library: 666–69.

Miner, James R., Richard O. Gray, Dana Stephens, and Michelle H. Biros. 2009. “Randomized Clinical Trial of Propofol with and without Alfentanil for Deep Procedural Sedation in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 16 (9). Wiley Online Library: 825–34.

Miner, James R. 2009. “Randomized Double-Blind Placebo Controlled Crossover Study of Acetaminophen, Ibuprofen, Acetaminophen/Hydrocodone, and Placebo for the Relief of Pain From a Standard Painful Stimulus.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 16 (9). Wiley Online Library: 911–14.

Miner, James R., Johanna Moore, Richard O. Gray, Lisa Skinner, and Michelle H. Biros. 2008. “Oral versus Intravenous Opioid Dosing for the Initial Treatment of Acute Musculoskeletal Pain in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 15 (12). Wiley Online Library: 1234–40.

Miner, James R. 2008. “The Surgical Stress Response, Preemptive Analgesia, and Procedural Sedation in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 15 (10). Wiley Online Library: 955–58.

Ducharme, James, Paula Tanabe, Peter Homel, James R. Miner, Andrew K. Chang, Jacques Lee, Knox H. Todd, and Pain and Emergency Medicine Initiative Study Group. 2008. “The Influence of Triage Systems and Triage Scores on Timeliness of ED Analgesic Administration.” The American Journal of Emergency Medicine 26 (8). Elsevier: 867–73.

Hill, Chandler H., James R. Miner, and Marc L. Martel. 2008. “Olanzapine versus Droperidol for the Treatment of Primary Headache in the Emergency Department.”Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 15 (9). Wiley Online Library: 806–11.

Miner, James R., Christine Kletti, Matthew Herold, Daniel Hubbard, and Michelle H. Biros. 2007. “Randomized Clinical Trial of Nebulized Fentanyl Citrate versus IV Fentanyl Citrate in Children Presenting to the Emergency Department with Acute Pain.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 14 (10). Blackwell Publishing Ltd: 895–98.

Miner, James R., and John H. Burton. 2007. “Clinical Practice Advisory: Emergency Department Procedural Sedation with Propofol.” Annals of Emergency Medicine 50 (2). Elsevier: 182–87, 187.e1.

Miner, James R., Darren Huber, Scott Nichols, and Michelle Biros. 2007. “The Effect of the Assignment of a Pre-Sedation Target Level on Procedural Sedation Using Propofol.”The Journal of Emergency Medicine 32 (3). Elsevier: 249–55.

Miner, James R., Mark Danahy, Abby Moch, and Michelle Biros. 2007. “Randomized Clinical Trial of Etomidate versus Propofol for Procedural Sedation in the Emergency Department.” Annals of Emergency Medicine 49 (1). Elsevier: 15–22.

Miner, James R., Stephen W. Smith, Johanna Moore, and Michelle Biros. 2007. “Sumatriptan for the Treatment of Undifferentiated Primary Headaches in the ED.” The American Journal of Emergency Medicine 25 (1). Elsevier: 60–64.

Miner, James R., Andrea Gaetz, and Michelle H. Biros. 2007/9. “The Association of a Decreased Level of Awareness and Blood Alcohol Concentration with Both Agitation and Sedation in Intoxicated Patients in the ED.” The American Journal of Emergency Medicine 25 (7). Elsevier: 743–48.

Miner, James, Michelle H. Biros, Arleigh Trainor, Daniel Hubbard, and Maryam Beltram. 2006. “Patient and Physician Perceptions as Risk Factors for Oligoanalgesia: A Prospective Observational Study of the Relief of Pain in the Emergency Department.”Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 13 (2). Wiley Online Library: 140–46.

Burton, John H., James R. Miner, Eric R. Shipley, Tania D. Strout, Chris Becker, and Henry C. Thode Jr. 2006. “Propofol for Emergency Department Procedural Sedation and Analgesia: A Tale of Three Centers.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 13 (1). Wiley Online Library: 24–30.

Miner, James R., Ryan Fringer, Todd Siegel, Andrea Gaetz, Louis Ling, and Michelle Biros. 2006. “Serial Bispectral Index Scores in Patients Undergoing Observation for Sedative Overdose in the Emergency Department.” The American Journal of Emergency Medicine 24 (1). Elsevier: 53–57.

Miner, James R., Andrew Bachman, Lindsey Kosman, Brian Teng, William Heegaard, and Michelle H. Biros. 2005. “Assessment of the Onset and Persistence of Amnesia during Procedural Sedation with Propofol.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 12 (6). academia.edu: 491–96.

Miner, James R., Michelle H. Biros, Todd Seigel, and Karen Ross. 2005. “The Utility of the Bispectral Index in Procedural Sedation with Propofol in the Emergency Department.”Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 12 (3). academia.edu: 190–96.

Miner, James R., Marc L. Martel, Madeline Meyer, Robert Reardon, and Michelle H. Biros. 2005. “Procedural Sedation of Critically Ill Patients in the Emergency Department.”Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 12 (2). Wiley Online Library: 124–28.

Martel, Marc, Ann Sterzinger, James Miner, Joseph Clinton, and Michelle Biros. 2005. “Management of Acute Undifferentiated Agitation in the Emergency Department: A Randomized Double-Blind Trial of Droperidol, Ziprasidone, and Midazolam.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 12 (12). Wiley Online Library: 1167–72.

Martel, Marc, James Miner, Ryan Fringer, Kristin Sufka, Alexander Miamen, Jeffrey Ho, Joseph Clinton, and Michelle Biros. 2005. “Discontinuation of Droperidol for the Control of Acutely Agitated out-of-Hospital Patients.” Prehospital Emergency Care: Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors 9 (1). Taylor & Francis: 44–48.

Haug, Eric, James Miner, Mark Dannehy, Todd Seigel, and Michelle Biros. 2004. “Bispectral Electroencephalographic Analysis of Head-Injured Patients in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 11 (4). Wiley Online Library: 349–52.

Miner, James R., Michelle Biros, Susan Krieg, Christopher Johnson, William Heegaard, and David Plummer. 2003. “Randomized Clinical Trial of Propofol versus Methohexital for Procedural Sedation during Fracture and Dislocation Reduction in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 10 (9). Wiley Online Library: 931–37.

Miner, James R., Michelle H. Biros, William Heegaard, and David Plummer. 2003. “Bispectral Electroencephalographic Analysis of Patients Undergoing Procedural Sedation in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 10 (6). Wiley Online Library: 638–43.

Miner, James R., William Heegaard, and David Plummer. 2002. “End-Tidal Carbon Dioxide Monitoring during Procedural Sedation.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 9 (4). Wiley Online Library: 275–80.

Miner, J. R., W. Heegaard, A. Mapes, and M. Biros. 2001. “Presentation, Time to Antibiotics, and Mortality of Patients with Bacterial Meningitis at an Urban County Medical Center.” The Journal of Emergency Medicine 21 (4). Elsevier: 387–92.

Miner, J. R., S. J. Fish, S. W. Smith, and M. H. Biros. 2001. “Droperidol vs. Prochlorperazine for Benign Headaches in the Emergency Department.” Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine 8 (9). Wiley Online Library: 873–79.